- Professeur - full Professor
- christine.imbert@univ-poitiers.fr
- +33 (0)5 49 45 43 55
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Doctorat de l’Université de Montpellier I, 1994 : Adhérence aux cellules épithéliales buccales humaines de souches de Candida albicans isolées chez des patients VIH+
HDR, Université de Poitiers, 2003
Mes activités de recherche portent sur les stratégies d’élimination des biofilms et sur la prévention de leur développement. Deux contextes m’intéressent tout particulièrement :
Biofilm ; Candida albicans ; Cutibacterium acnes ; amibes libres – antifongique ; traitement ; soins dentaires ; substances naturelles
Tel : +33 (0)5 49 45 36 87
Email : christine.imbert@univ-poitiers.fr
PhD, University of Montpellier, 1994: adherence of Candida albicans strains isolated from HIV+ patients to buccal epithelial cells
HDR, University of Poitiers, 2003
My research topics focus on strategies to eradicate biofilms and to prevent their development, with two main axes:
Search for new anti-biofilm treatments active against Candida spp
Biofilms can develop on biotic and abiotic substrates, espceially indwelling medical devices. Once they adopt this biofilm lifestyle, Candida yeasts become poorly susceptible to conventional antifungal agents. We thus investigate new compounds and strategies able to prevent formation or to eradicate already formed Candida spp. biofilms. Thanks to several in vitro models mimicking the growth of Candida spp. biofilms, we evaluate the anti-biofilm interest of different molecules, both natural components (essential oils, phenolic components, terpenes, etc) and synthetic molecules. Several therapeutic approaches are investigated, such as systemic and lock approaches.
Infectious risks associated to water in the context of dental cares
This part focuses on the study of infectious risks associated with the development of a complex biofilm in dental unit waterlines (DUW). Microorganisms from both oral cavity and environment can be isolated in the dental unit (hand pieces) output water ; these microorganisms may grow and interact inside biofilms growing in dental unit waterlines. Water and aerosols generated during dental cares may represent an infectious risk for patients and dental staff, in particular for immunocompromised and elderly persons. We investigate the microbial ecology in DUW (16S and 18S). We also investigate the activity of disinfectants used by dentist staff for DUW maintainance and the particular influence of free living amoebae. We work both with real dental units (collaboration with dentists) and with lab models.
Biofilm – cathéter – Candida – antifongique – biocide – amibes libres – eau – soins dentaires – huiles essentielles
Tel : +33 (0)5 49 45 36 87
Email : christine.imbert@univ-poitiers.fr